Bladder Exstrophy-Epispadias-Cloacal Exstrophy Complex

National Organization for Rare Disorders, Inc.

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It is possible that the main title of the report Bladder Exstrophy-Epispadias-Cloacal Exstrophy Complex is not the name you expected.

Disorder Subdivisions

  • None

General Discussion

Bladder exstrophy-epispadias-cloacal exstrophy complex is a spectrum of anomalies involving the urinary tract, genital tract, musculoskeletal system and sometimes the intestinal tract. In classic bladder exstrophy, most anomalies are related to defects of the abdominal wall, bladder, genitalia, pelvic bones, rectum and anus.

Bladder exstrophy is a rare developmental abnormality that is present at birth (congenital) in which the bladder and related structures are turned inside out. The rear portion of the bladder wall (posterior vesical wall) turns outward (exstrophy) through an opening in the abdominal wall and urine is excreted through this opening. The extent of the exstrophy depends on how large the opening is. The mildest form is when there is a defect or opening in the tube that carries urine out of the body from the bladder (urethra) and is termed epispadias.

The most severe form is when there is a defect in the urethra, bladder and bowel (cloacal exstrophy). Classic bladder exstrophy is when there is a defect in the urethra and bladder and is intermediate in severity. The underlying cause of this complex is not known. The physical characteristics are the result of a developmental abnormality during embryonic growth in which the cloacal membrane is not replaced by tissue that will form the abdominal muscles.

Supporting Organizations

Association For Bladder Exstrophy Community

6737 West Washington Street
Suite 6737
West Allis, WI 53214
Tel: (414)918-9002
Tel: (866)300-2222

Birth Defect Research for Children, Inc.

976 Lake Baldwin Lane
Orlando, FL 32814
Tel: (407)895-0802

Genetic and Rare Diseases (GARD) Information Center

PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311

NIH/National Kidney and Urologic Diseases Information Clearinghouse

3 Information Way
Bethesda, MD 20892-3580
Fax: (703)738-4929
Tel: (800)891-5390

National Association for Continence

P.O. Box 1019
Charleston, SC 29402-1019
United States
Tel: (843)377-0900
Fax: (342)377-0905
Tel: (800)252-3337

Pull-Thru Network

1705 Wintergreen Parkway
Normal, IL 61761
Tel: (309)262-2930

Ureterosigmoidostomy Association

P.O. Box 392
Brunswick, ME 4011
Tel: (207)725-2753

Urology Care Foundation

1000 Corporate Blvd
Linthicum, MD 21090
Tel: (410)689-3700
Fax: (410)689-3896
Tel: (800)828-7866

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). For a full-text version of this report, go to and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report.

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

Last Updated:  8/17/2007
Copyright  2007 National Organization for Rare Disorders, Inc.